The online home based business opportunity is usually a small business, which requires smart actions more than big budgets. By the smart action I mean the efforts, their costs and whether they have long term or one shot influences. Have you planned your online home based business opportunity?
1. The Limits Of A One Man Operation.
If the online home based business opportunity is ran by one person, who does it as a half timer, the weekly hours, which he can use for this work are really limited and can even hinder the expansion of the business. What could he do? The first thing is to concentrate on the planning and on the leadership of the operation.
Today it is relatively easy and cheap to use freelancers and let them do the hard work. The success of the online home based business opportunity will be determined as a result of a smart planning.
This is one thing, but as important is to plan only the residual actions, i.e. the actions, which will influence during a long period of time. This saves energy and increase the ability to compete, because the business is built with a brick on brick technique.
2. The Importance Of The Residual Actions.
For instance, a PPC campaign can bring a nice amount of visitors, but think how much work will it need and what are the costs? The visitors come quickly and so comes the revenue, but then it is all gone. If you market with the optimized marketing articles, the results come step by step, with the growing influences, but they keep coming month after month and all new articles build results on the top of the old ones.
3. The Residual Actions Support Each Other.
This is also true and important. When you will write an optimized article with a certain main keyword and distribute it to several article directories, it will increase the search engine ranking. The next article with the same keyword will do exactly the same and the next one and the next one. In this way it is possible to build strong search engine rankings, which will last for a long time.
4. The Economy.
We all small business marketers have limited funds in use compared with the big companies. That means, that we have to work economically, i.e. to try to run actions, which bring the maximum amount of results with a minimum amount of budget. Again, we have to run campaigns, which have residual influences.
5. The Art Of The Outsourcing.
The Internet is a fantastic source of services. Your online home based business opportunity can find free lancers for many purposes and the prices are quite low. Maybe the hardest thing is to find, for instance, a writer who has the style which fits to you. By the outsourcing it is possible to build a big online company, which has only one person with the fixed salary, you. To be honest, also that person has to cut the salary, when needed.
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Forum to focus on innovative ways employers can break their rising healthcare cost trend
?The Healthcare Delivery Innovation Alliance (HDIA) will host a forum focusing on innovative ways employers can address rising healthcare costs and employee satisfaction in the delivery of healthcare services. The forum, which will feature national and state experts in healthcare is being held Thursday, March 1, from 8 a.m. to 10:30 a.m. in Phoenix at the Sheraton Phoenix Downtown Hotel.
Speakers will advise on best practices to improve healthcare cost effect on a company?s bottom line, and will address a variety of healthcare reform topics. Executives from employers, healthcare organizations, insurance companies, benefits brokers/consultants, and the media are welcome to join.
Event:
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Healthcare Delivery Innovation Forum: Breaking the Cost Trend
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FeaturedSpeakers:
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The Honorable Nancy Barto, Arizona State Senator ? Chairman of the Healthcare & Medical Liability Reform committee
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Dr. Bob Graboyes, MSHA, PhD, Senior Fellow for Health and Economics at NFIB Research Foundation
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Michael Cohen, Vice President of Marketing, WhiteGlove Health
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When:
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Thursday, March 1, 8 a.m. to 10:30 a.m.
Where:
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Sheraton Phoenix Downtown, Paradise Valley Room
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No charge, light breakfast to be served
The event will be held over breakfast. Sign-up is free to the public, but space is limited. Registration can be found on the HDIA.org events page.?Information about the HDIA and the forum, as well as a draft of the organization?s charter, can be found at www.hdia.org.
About the Healthcare Delivery Innovation Alliance
The Healthcare Delivery Innovation Alliance (HDIA) is a 501(c)(4), non-profit membership organization whose members are leaders in healthcare services and technology, business, government, and academia. HDIA members include executives at Avado Inc., Innosight Institute; Lockton, Inc.; WhiteGlove Health; Lancaster Pollard; the Healthcare Properties Group of Grubb & Ellis; St. David?s Healthcare; the American Academy of Nurse Practitioners; the NFIB Research Foundation; Southwest Airlines and State Farm Insurance.
The HDIA is working to identify and advance standards for new healthcare delivery systems that expand access, lower costs and improve the patient experience. For membership information, please visit www.HDIA.org.
Email Cash Secrets Fast and Easy Money Making Strategies For New Email Marketers! Finally Revealed! Insider Trade Secrets To Making A Fortune With Simple Email Marketing Strategies!
That?s a strong claim to make ? that if you do have an?email marketing list it can make your Internet business succeed, and if you don?t, it can break your business.
Imagine, you have an online business and everything is going well ? your website pages are all high in the SERPS, you are getting tons of traffic, you are turning that traffic into orders easily and well.? The money is rolling in.
That is the best feeling ever.? You are doing something right.
Then imagine, Google changes it?s algorithm.? Or a new product comes out that takes focus from whatever you are trying to promote.? Or one of the products you promote goes under for some reason.? Or you get sick and can?t work for a while.
Whatever your business model is, something throws a wrench in it and it comes to a slow, grinding, torturous halt.? Your income slows.? You don?t know what to do.
What do you do?? Everything possible to get back what you had, of course, but what if it doesn?t work fast enough?? What if the bills start coming due and you have no money flowing in?? You might even consider trying to get a j.o.b.? (gasp!)
But then imagine, that you have an email marketing list.? Imagine you have several thousand people who have said ?yes, you can have my email address and if you send interesting enough information, I may read it.?
Imagine, if you could turn to this list and tell them ?hey, my product (or whatever I am promoting) is still here and still good ? take a look at it.?
Or, since you know these people and you know what they are interested in, you could send them new offers.?? Something you?ve bought and used yourself that you know they would like.
Or a new, bundled product you put together specially.? Or anything that you know a list like this would be interested in.
And then, even though you?re in crisis mode, you still have an income.? There?s still money coming in.? And you have time to sit back and regroup, and then come roaring back stronger than ever.
So, that?s the way an email marketing list can SAVE YOUR BUTT in bad times.? The people on your list can?t ever be taken away from you.? Google can?t take them, a hacker can?t steal them, and even a business crisis won?t stop them from buying.
And that?s just one way an email marketing list can help you.? A growing and responsive list can be a boon while your business is thriving too.
They can be the first group of people you market your new products too.? They can give immediate feedback on new products and directions your business is going in.
Your list members can be your own personal market testers.? If they buy strong, you know you?ve got something good.? If they express interest, you know you can see results from your new products as soon as they are available.
There doesn?t have to be any waiting for a months worth of traffic to see a substantial return.? You can develop a new product, send the information to your email marketing list, and see how they respond within hours.? (You can have sales within minutes).
In short, there may be nothing more valuable to an online business than email marketing done right.? Start your email marketing list today.
Related posts:
Online Email Marketing, How Do You Make Money?
How To Make Money From Your Email Marketing List
Email Marketing Ideas To Help You Expand Your Online Business
Use Effective Email Marketing To Help Your Online Business Thrive
Email Marketing ? The Money is in the List; Myth or Fact?
[unable to retrieve full-text content]AP - Even the hundreds of photographers, TV cameras and webcams around the Hollywood & Highland Center can't capture every starry moment of Sunday's 84th annual Academy Awards.
The extraordinary political crisis that is tearing the Australian government and the Labor Party apart is due to come to a head on Monday with a leadership contest between Prime Minister Julia Gillard and ex-foreign minister Kevin Rudd. In the media, however, this fundamental rift is being portrayed, in the words of today?s Australian editorial, as ?not about policy, nor about national interest... [but] about petty squabbles of the past, revenge colliding with retribution, and the politics of personality.?
In other words, the vitriol being vented by Rudd and Gillard supporters against their opponents in the leadership battle, unparalleled in post-war Australian political history, has nothing to do with fundamental policy differences. The Labor Party?the country?s oldest party, on which the Australian ruling class has relied in every major crisis over the past century?is supposedly imploding because of the overweening ambition of two individuals.
This version of events is simply nonsensical.
The underlying causes of the conflict are not to be found, primarily, in the sphere of domestic politics. Both Rudd and Gillard are committed to the austerity agenda demanded by finance capital and are pitching themselves to big business as the best instrument for implementing the required assault on the working class.
Rather, the fracturing of the Labor Party is bound up with powerful geo-political rivalries centred on the Obama administration?s growing confrontation with China. The Australian ruling class has been swept into this maelstrom, confronted point blank with the longstanding dilemma posed by its heavy economic dependence on China, on the one hand, and its geo-strategic reliance on its military alliance with the United States, on the other.
Rudd was removed as prime minister in June 2010 in an overnight inner-party coup carried out by a handful of factional leaders with close ties to Washington. At the time, Obama had just begun his foreign policy ?pivot? from the Middle East to an aggressive diplomatic and strategic intervention in Asia, aimed at undermining China?s expanding influence.
The Obama administration regarded Rudd as an obstacle to its orientation. This was not because he in any way threatened the US-Australia alliance, as evidenced in a WikiLeaks cable, in which he described himself to American officials as ?a brutal realist? who recognised that a US war with China could eventually take place.
Rudd, however, did propose the creation of a regional forum through which the economic and strategic interests of the United States and China could be accommodated by deft negotiation and diplomatic summitry. This cut across Obama?s intention, which was not to ease tensions, but rather to heighten the pressure on China across the Indo-Pacific region. He did not want a diplomatic mediator in Canberra, but a staunch, unquestioning ally.
Nearly two years later, US-China tensions have dramatically intensified. Gillard has proven her worth by slavishly supporting every Obama initiative. She announced last November that the US military, including US Marines, would have access to Australian military bases across the north and west of the country, adjacent to highly sensitive shipping lanes through which China gains access to energy and raw materials from the Middle East and Africa.
As foreign minister, Rudd has toed the US line on myriad issues, including the NATO military intervention in Libya. But he has also continued to proselytise in international forums on the need for a Pax Pacifica, as he told the Asia Society in Washington in January??a peace that will ultimately be anchored in the principles of common security, recognising the realities of US and Chinese power.?
This political divide is not limited to the present Labor leadership, to the Labor Party or to Australia. Former Labor Prime Minister Paul Keating and ex-Liberal Party opposition leader Malcolm Turnbull publicly expressed concerns last November about Obama?s confrontational approach to China. Keating ousted Bob Hawke as Labor leader in 1991 in part in order to pursue a closer orientation to Asia. Turnbull, who was removed as Liberal Party leader in late 2009, exemplifies the foreign policy split in the opposition?s ranks.
Similar dilemmas confront the political establishments in the US, Europe and internationally, where powerful economic and financial interests are heavily dependent on investment in China. The auto giant General Motors, for example, would quickly plunge into the red if its highly profitable operations in China were significantly compromised. Over the past decade, US exports to China have increased by 468 percent, and trade between the two countries is expected to hit half a trillion dollars this year.
Rudd is therefore not alone in his views. Former US National Security Adviser, Zbigniew Brzezinski, wrote in the closing pages of his new book, Strategic Vision: ?An active American role in Asia is essential not only in order to promote stability in the region but, even more so, to create circumstances in which the American-Chinese relationship evolves peacefully and cooperatively, and eventually grows into a wide-ranging political and economic global partnership.?
Another US foreign policy heavyweight, Henry Kissinger, who was instrumental in securing US-China rapprochement in 1972, has also called for renewed cooperation and expressed fears of a confrontation. In his book On China published last year, he warned that a cold war with China ?would arrest progress for a generation on both sides of the Pacific? and would ?spread disputes into internal politics of every region.?
Significantly Kissinger chaired a session of the top-level Munich Security Conference earlier this month, at which Rudd repeated his call for a Pax Pacifica that would accommodate China?s ?legitimate search for national sovereignty? as well as ?the US continuing strategic engagement in Asia.? He made a particular appeal to the European powers to use their ?common security and foreign policy voice... to help shape this emergence of a sense of common security across wider Asia.?
These appeals for compromise and reason stand in sharp contrast to the escalating geo-political tensions that are being driven, above all, by the historic decline of US imperialism. In an attempt to retain its global hegemony, the US has, over the past two decades, used its overwhelming military might to wage a series of criminal wars in the Middle East, the Balkans and Central Asia aimed at undermining its major competitors. Faced with the rapid economic rise of China, the Obama administration is now recklessly confronting what it regards as a potential global rival to the US across the Asian region.
The basic fault lines of new conflicts are rapidly emerging, which, as long as capitalism remains, will plunge humanity into a new and catastrophic world war. Never before in history has the world economy been more closely intertwined, yet that very global integration has only exacerbated the conflicts and contradictions within the outmoded capitalist nation state system.
It is not accidental that these deep-going tensions take particularly explosive form in Australia. No other country in the world is so dependent on China as an export market for its commodities?iron ore, coal and minerals?and at the same time so reliant on the military strength of US imperialism to guarantee its own regional strategic interests. None of these issues can be discussed publicly, precisely because to do so would only compound the dilemma and alert the working class to the perils it faces.
Far from being an inconsequential personality clash, the Australian political crisis must act as a warning to workers and youth around the world about the dangers of the escalating drive to war and the need to unify the working class internationally in the common struggle to overthrow the capitalist system and establish workers? governments based on the program of socialist internationalism.
[unable to retrieve full-text content]AP - The Academy Awards are a big deal — even to A-listers. That's why a parade of stars came through the theater at the Hollywood & Highland Center Saturday to run through their lines and prepare to address their peers in front of a worldwide audience of millions.
Featuring voice guided directions using built-in speakers; a fast 400 MHz processor; a high sensitivity, SiRFstart III GPS antenna; and a compact, pocket-friendly design; the one-inch thick Delphi NAV200 GPS navigation system is a great choice when you want powerful GPS navigation at your fingertips. Flexible and versatile, this system also lets you take advantage of entertainment features in the back seat,
Small and pocketable, the NAV200 goes where you do. Compare the NAV200 with other GPS units.
3D map view makes navigation easy.
A slim profile and logical controls. at home, or on the go; simply use the three hour, built-in, rechargeable battery.
The NAV200?s 3.5-inch, anti-glare display supports a resolution of 320 x 240 pixels, giving you plenty of real estate to view the road ahead and control the device?s functions via the touchscreen interface. A powerful processor quickly calculates your route using one of the most trusted mapping databases in the industry. The included 1.5 GB SD card comes preloaded with NAVTEQ maps of the U.S. and Canada. Useful and fun extras include an MP3 music player for listening to your favorite songs as you drive, a picture viewer, a movie player, a game (Othello), a world clock, and a calculator. The unit is also RDS real-time traffic ready, meaning that with the purchase of an optional TMC FM radio antenna and service, you can receive up to the minute traffic conditions along your route.
A colorful, easy-to-read user interface makes navigation a snap. Large icons help you control the unit with just a glance, and a 3D map view keeps you on top of upcoming maneuvers. Meanwhile, clear voice prompts help you keep your eyes on the road.
Installation of the NAV200 is easy, too, thanks to the suction goose-neck windshield mount. When it?s time to move the NAV200, it dismounts quickly and easily, so you can take it for a walk through town or in and out of your rental car.
What?s in the Box NAV200 GPS unit, cigarette lighter adapter, windshield mount, dashboard mount, stylus pen, DVD with user?s manual and backup map data files, SD card (1.5 GB) preloaded U.S. and Canada map, quick start guide, and customer service card.
Pocket-sized portable navigation system comes pre-loaded with NAVTEQ maps of the Continental U.S. (Excludes Alaska, Hawaii and Puerto Rico) Features voice guided directions using built-in speakers, and a powerful 400 MHz processor with a high sensitivity, SiRFstart III GPS antenna Includes an MP3 music player for listening to your favorite songs as you drive, a picture viewer, movie player, game, world clock, and calculator Large, 3.5-inch touch screen with easy-to-read, colorful icons; easy to install with the suction goose-neck windshield mount Weighs 2.3 pounds
Product Dimensions: 5.3 x 1 x 3.2 inches Shipping Weight: 2 pounds ASIN: B000JE6XAS Item model number: NA20000
Delphi NAV200 GPS Navigation System - NAV20000-11B1Portable Vehicle GPS Units)
ChargerCity GPS Vehicle Power Cable Car Charger Adapter Cord for Delphi NAV200 NAV300 NAV400 NAV 200 300 400 GPS Models (9ft Coiled Cable for Longer Reach & Easy Storage)
ChargerCity Vehicle Charger power cable Cord Adapter for Delphi Nav 400 and NAV 300 models
Brand New, High Quality Rapid Car POWER Charger Adapter Cable Cord Input: 12v ? 24v, Output: 5v 1A Build in Dynamic IC Charge IC & Power fuse for rapid charging and over charge protection Extended 9 ft Coiled cable ChargerCity Manufacture Direct Warranty
ChargerCity GPS Vehicle Power Cable Car Charger Adapter Cord for Delphi NAV200 NAV300 NAV400 NAV 200 300 400 GPS Models (9ft Coiled Cable for Longer Reach & Easy Storage)GPS Cables)
This entry was posted on Thursday, February 23rd, 2012 at 8:15 pm and is filed under Electronics Products. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.
There are numerous individuals coming to the medical arena due to the job acceleration and job stability. You can easily begin a vocation even if you do not have a durable informative background. All you require is to have a caring and empathetic personality. You will certainly be offered a couple of weeks instruction that will certainly make permit you to pass the certification. When you have passed the assessment and get the certificate, you are able to begin working as the CNA training. Besides this, you can either work in hospitals by assisting the signed up nurses by having their daily program or you can work one at a time by going to individuals to their residence. The newly certified nursing assistants get paid hourly and the per hr prices begin from $ 10 which is significantly a high pay scale price. When it concerns the breastfeeding, you constantly have the exceptional job opportunities by nursing continuing learning.
There are always career further development seminars and trainings to increase your abilities at work and grow even more. You can easily begin the vocation as a licensed however then this is not the end. You always need the chance to increase more, if you have a high school diploma you can become a registered efficient nurse. The basic instruction is for 9 to 18 months however the period differs as there are lots of universities supplying the instruction in less time. Students will be going to classes and likewise doing the clinical tasks. After finishing the training, pupils are required to pass a license exam call NCLEX-PN. Once you will certainly get the license you will certainly be working as a registered functional nurse. The primary responsibilities are to check out the important signs for the people and preparing injections for people. Even, you could have to execute some added yet simple research laboratory tests and follow the instructions offered by the signed up nurses and doctors. You can easily make progress by nursing continuing learning to become a registered nurse.
The signed up nurse has the highest rank among the nurses working in a hospice. There are three academic ways to come to be a signed up nurse; first of all, you have to pass a bachelor qualification for the breastfeeding that is BSN or Bachelor of Sciences in Nursing. You can take classes in different universities and universities; you can additionally turn into a signed up nurse by getting the training from a community college and usually the duration for these programs are two to three years. Beyond this, you could likewise get a voucher administrated by the clinic. The period for the clinic voucher is approximately three years.
If you are working as a certified efficient nurse and you want to come to be a registered nurse then you are able tocna traininggo for the diploma training. To turn into a registered nurse, after finishing the signed up nursing training you need to pass the license examination too. There are also fabulous vocation developments by breastfeeding going on education.
A registered nurse is able to also turn into the school nurse after getting some experience and passing an accreditation which is held under the direction of State Medical Association.
Obtain a lot more details about cna salary info in our recent post aboutFinding That First Position After CNA Instruction Can Seem Difficult. Check out our internet site about cna courses for additional facts.
Researchers reveal how cancer cells change once they spread to distant organsPublic release date: 22-Feb-2012 [ | E-mail | Share ]
Contact: Richard Pietzak riz2008@med.cornell.edu 212-821-0560 New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Cornell Center on the Microenvironment and Metastasis and Neuberger Berman Lung Cancer Research Center findings suggest targeting a single protein may help stop cancer spread
NEW YORK (Feb. 22, 2012) -- Oncologists have known that in order for cancer cells to spread, they must transform themselves so they can detach from a tumor and spread to a distant organ. Now, scientists at Weill Cornell Medical College have revealed critical steps in what happens next -- how these cells reverse the process, morphing back into classical cancer that can now grow into a new tumor.
Their findings, now published online and in a upcoming issue of Cancer Research and funded through a National Cancer Institute grant to the Cornell Center on the Microenvironment and Metastasis and the Neuberger Berman Foundation, show that a single protein, versican, is key to this process in breast cancer, the tumor they studied. When researchers stopped versican from functioning in mice, breast cancer could not "seed" themselves into the lungs and form secondary tumors.
"Our findings both help us understand how breast cancer metastasizes to the lungs and ways to possibly prevent that deadly spread," says the study's senior investigator, Dr. Vivek Mittal, an associate professor of cell and developmental biology in cardiothoracic surgery and director of the Neuberger Berman Lung Cancer Laboratory at Weill Cornell Medical College.
"These are exciting insights into a poorly investigated area," Dr. Mittal says. "There are no clinically approved drugs now that can effectively target metastatic lesions, which is why more than 90 percent of human cancer-related deaths come from spread of the disease from a primary tumor."
"The results of this study are a critical step in deconstructing the process of metastases -- which is critical to curing our patients," says co-author Dr. Linda T. Vahdat, professor of medicine, chief of the Solid Tumor Service and director of the Breast Cancer Research Program at Weill Cornell. "As a direct result of this study, we are working on ways to interrupt the process by which tumors co-opt the infrastructure in our bodies to grow and spread."
This important study starts to unravel the mechanistic basis of cancer metastases, not only in breast cancer but possibly in other types of cancer, says Dr. Nasser Altorki, the David B. Skinner Professor of Thoracic Surgery at Weill Cornell Medical College and director of the division of thoracic surgery at NewYork-Presbyterian/Weill Cornell. "The need for a prepared and receptive soil may be required for cancer cell seeding regardless of the primary cancer's site of origin."
The Seed and the Soil
Cancer researchers have believed that for a cancer to spread, its "seed" must find the right "soil" in a distant organ in order to thrive. And they have hypothesized that this seed is formed through a process known as epithelial-mesenchymal transition (EMT), in which cancer cells lose their sticky grip to other cells in a primary tumor and become more mobile, able to travel through the blood to a distant organ.
But what happens next is conjecture. Scientists have speculated that the cells undergo a reverse process, called mesenchymal-epithelial transition (MET), in which the cancer seeds morph back into epithelial cells that can make contact with tissue and integrate in the new organ. Little is known about MET compared to EMT.
In this study, Dr. Mittal, along with his colleagues at Weill Cornell, studied mouse models of spontaneous breast cancer development. They first discovered that primary breast tumors send a signal that forces bone-marrow-derived hematopoietic cells to move into the lungs of the mice. "This appears to be the soil the cancer seeds need," says Dr. Mittal. The next question was obvious: What is it about the soil that helps the seed?
The team found that a subtype of these bone marrow cells expressed versican, which allowed the cancer cells, once they traveled to the lungs, to morph back into epithelial cells. "The primary tumor sets up the lung microenvironment to promote metastasis," he says. "MET resulted not from properties within the cancer cell itself, but due to a unique crosstalk between the microenvironment and tumor cells in the lung."
In their next experiment, the researchers blocked versican production by injecting small interfering RNAs (siRNAs) in the bone marrow that silenced the versican gene, which prevented MET and blocked tumor outgrowth in the lung.
Human Tumors Express Versican
Next, they investigated human breast metastases to the lung, utilizing lung samples obtained from breast cancer patients contributed by researchers at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University. "We found versican was highly expressed in those lung tumors, which matched what we found in our mice," Dr. Mittal says. "This all made sense to us, because versican has been linked to cancer progression, although no one knew why.
"This is the first study demonstrating the significance of MET in the formation of macrometastases in distant organs," Dr. Mittal says. "Given the findings, we now have a potential strategy to stop cancer spread before it starts, or to shut it down if it has already occurred."
###
The study was funded by support from the Neuberger Berman Lung Cancer Laboratory, the Robert I. Goldman Foundation and National Cancer Institute support of the Cornell Center on the Microenvironment and Metastasis.
Study co-authors include, from Weill Cornell Medical College: Dingcheng Gao, Natasha Joshi, Hyejin Choi, Seongho Ryu, Mary Hahn, Raul Catena, Patrick Wagner, Linda T. Vahdat, Jeffrey L. Port, Brendon Stiles and Nasser K. Altorki; from Johns Hopkins University: Saraswati Sukumar, Helen Sadik and Pedram Argani; and Shahin Rafii from the Howard Hughes Medical Institute and Weill Cornell Medical College.
Weill Cornell Medical College
Weill Cornell Medical College, Cornell University's medical school located in New York City, is committed to excellence in research, teaching, patient care and the advancement of the art and science of medicine, locally, nationally and globally. Physicians and scientists of Weill Cornell Medical College are engaged in cutting-edge research from bench to bedside, aimed at unlocking mysteries of the human body in health and sickness and toward developing new treatments and prevention strategies. In its commitment to global health and education, Weill Cornell has a strong presence in places such as Qatar, Tanzania, Haiti, Brazil, Austria and Turkey. Through the historic Weill Cornell Medical College in Qatar, the Medical College is the first in the U.S. to offer its M.D. degree overseas. Weill Cornell is the birthplace of many medical advances -- including the development of the Pap test for cervical cancer, the synthesis of penicillin, the first successful embryo-biopsy pregnancy and birth in the U.S., the first clinical trial of gene therapy for Parkinson's disease, and most recently, the world's first successful use of deep brain stimulation to treat a minimally conscious brain-injured patient. Weill Cornell Medical College is affiliated with NewYork-Presbyterian Hospital, where its faculty provides comprehensive patient care at NewYork-Presbyterian Hospital/Weill Cornell Medical Center. The Medical College is also affiliated with the Methodist Hospital in Houston. For more information, visit weill.cornell.edu.
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Researchers reveal how cancer cells change once they spread to distant organsPublic release date: 22-Feb-2012 [ | E-mail | Share ]
Contact: Richard Pietzak riz2008@med.cornell.edu 212-821-0560 New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Cornell Center on the Microenvironment and Metastasis and Neuberger Berman Lung Cancer Research Center findings suggest targeting a single protein may help stop cancer spread
NEW YORK (Feb. 22, 2012) -- Oncologists have known that in order for cancer cells to spread, they must transform themselves so they can detach from a tumor and spread to a distant organ. Now, scientists at Weill Cornell Medical College have revealed critical steps in what happens next -- how these cells reverse the process, morphing back into classical cancer that can now grow into a new tumor.
Their findings, now published online and in a upcoming issue of Cancer Research and funded through a National Cancer Institute grant to the Cornell Center on the Microenvironment and Metastasis and the Neuberger Berman Foundation, show that a single protein, versican, is key to this process in breast cancer, the tumor they studied. When researchers stopped versican from functioning in mice, breast cancer could not "seed" themselves into the lungs and form secondary tumors.
"Our findings both help us understand how breast cancer metastasizes to the lungs and ways to possibly prevent that deadly spread," says the study's senior investigator, Dr. Vivek Mittal, an associate professor of cell and developmental biology in cardiothoracic surgery and director of the Neuberger Berman Lung Cancer Laboratory at Weill Cornell Medical College.
"These are exciting insights into a poorly investigated area," Dr. Mittal says. "There are no clinically approved drugs now that can effectively target metastatic lesions, which is why more than 90 percent of human cancer-related deaths come from spread of the disease from a primary tumor."
"The results of this study are a critical step in deconstructing the process of metastases -- which is critical to curing our patients," says co-author Dr. Linda T. Vahdat, professor of medicine, chief of the Solid Tumor Service and director of the Breast Cancer Research Program at Weill Cornell. "As a direct result of this study, we are working on ways to interrupt the process by which tumors co-opt the infrastructure in our bodies to grow and spread."
This important study starts to unravel the mechanistic basis of cancer metastases, not only in breast cancer but possibly in other types of cancer, says Dr. Nasser Altorki, the David B. Skinner Professor of Thoracic Surgery at Weill Cornell Medical College and director of the division of thoracic surgery at NewYork-Presbyterian/Weill Cornell. "The need for a prepared and receptive soil may be required for cancer cell seeding regardless of the primary cancer's site of origin."
The Seed and the Soil
Cancer researchers have believed that for a cancer to spread, its "seed" must find the right "soil" in a distant organ in order to thrive. And they have hypothesized that this seed is formed through a process known as epithelial-mesenchymal transition (EMT), in which cancer cells lose their sticky grip to other cells in a primary tumor and become more mobile, able to travel through the blood to a distant organ.
But what happens next is conjecture. Scientists have speculated that the cells undergo a reverse process, called mesenchymal-epithelial transition (MET), in which the cancer seeds morph back into epithelial cells that can make contact with tissue and integrate in the new organ. Little is known about MET compared to EMT.
In this study, Dr. Mittal, along with his colleagues at Weill Cornell, studied mouse models of spontaneous breast cancer development. They first discovered that primary breast tumors send a signal that forces bone-marrow-derived hematopoietic cells to move into the lungs of the mice. "This appears to be the soil the cancer seeds need," says Dr. Mittal. The next question was obvious: What is it about the soil that helps the seed?
The team found that a subtype of these bone marrow cells expressed versican, which allowed the cancer cells, once they traveled to the lungs, to morph back into epithelial cells. "The primary tumor sets up the lung microenvironment to promote metastasis," he says. "MET resulted not from properties within the cancer cell itself, but due to a unique crosstalk between the microenvironment and tumor cells in the lung."
In their next experiment, the researchers blocked versican production by injecting small interfering RNAs (siRNAs) in the bone marrow that silenced the versican gene, which prevented MET and blocked tumor outgrowth in the lung.
Human Tumors Express Versican
Next, they investigated human breast metastases to the lung, utilizing lung samples obtained from breast cancer patients contributed by researchers at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University. "We found versican was highly expressed in those lung tumors, which matched what we found in our mice," Dr. Mittal says. "This all made sense to us, because versican has been linked to cancer progression, although no one knew why.
"This is the first study demonstrating the significance of MET in the formation of macrometastases in distant organs," Dr. Mittal says. "Given the findings, we now have a potential strategy to stop cancer spread before it starts, or to shut it down if it has already occurred."
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The study was funded by support from the Neuberger Berman Lung Cancer Laboratory, the Robert I. Goldman Foundation and National Cancer Institute support of the Cornell Center on the Microenvironment and Metastasis.
Study co-authors include, from Weill Cornell Medical College: Dingcheng Gao, Natasha Joshi, Hyejin Choi, Seongho Ryu, Mary Hahn, Raul Catena, Patrick Wagner, Linda T. Vahdat, Jeffrey L. Port, Brendon Stiles and Nasser K. Altorki; from Johns Hopkins University: Saraswati Sukumar, Helen Sadik and Pedram Argani; and Shahin Rafii from the Howard Hughes Medical Institute and Weill Cornell Medical College.
Weill Cornell Medical College
Weill Cornell Medical College, Cornell University's medical school located in New York City, is committed to excellence in research, teaching, patient care and the advancement of the art and science of medicine, locally, nationally and globally. Physicians and scientists of Weill Cornell Medical College are engaged in cutting-edge research from bench to bedside, aimed at unlocking mysteries of the human body in health and sickness and toward developing new treatments and prevention strategies. In its commitment to global health and education, Weill Cornell has a strong presence in places such as Qatar, Tanzania, Haiti, Brazil, Austria and Turkey. Through the historic Weill Cornell Medical College in Qatar, the Medical College is the first in the U.S. to offer its M.D. degree overseas. Weill Cornell is the birthplace of many medical advances -- including the development of the Pap test for cervical cancer, the synthesis of penicillin, the first successful embryo-biopsy pregnancy and birth in the U.S., the first clinical trial of gene therapy for Parkinson's disease, and most recently, the world's first successful use of deep brain stimulation to treat a minimally conscious brain-injured patient. Weill Cornell Medical College is affiliated with NewYork-Presbyterian Hospital, where its faculty provides comprehensive patient care at NewYork-Presbyterian Hospital/Weill Cornell Medical Center. The Medical College is also affiliated with the Methodist Hospital in Houston. For more information, visit weill.cornell.edu.
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Home ? ALL ? Donate a Buck to the Boobies | K2 Bumps Challenge For Breast Cancer Awareness
This Saturday February 25th is the K2 Bumps Callenge for Breast Cancer Awareness?at Taos, NM. This event is like a walk-a-thon, except instead of walking around a flat boring high school track participants will be raging as many runs down the infamous Al?s Run under Taos?s Chair 5 as possible in 4 hours. ?Al?s is 1800 vert of mean and I am sure that we are all going to be really tired by the end of 4 hours of sprinting down steep moguls as fast as possible. I am a big fan of the main benefactor of this event and I would guess that most guys and gals out are also.?
That is right, ?we ?will be tired. ?I will be heading down to Taos to give my good friend Joe Augusten a run for his money in this event. Joe is guaranteeing victory and is backing it up with his own money. To give him a little more motivation and competition I figured the least I could do was dust off the old mogul skills and drive down. We are thinking that 16+ runs is totally possible, with a stretch goal of 20 being talked about.?All donations will go towards two breast cancer charity organizations.
Please contact me asap if you are interested in pledging for the awesome charity event. You can donate a dollar amount per run, or just a flat fee. Please hit me up at Daryn@unoffiicialnetworks.com asap! ?Thanks!
The Al's Run....
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About the author
Daryn Edmunds grew up shredding the bad ass hills of lower NY. After college he moved out to SLC to ski in Little Cottonwood Canyon. He now sells Real Estate and runs Unofficial Snowbird. Contact: Daryn@unofficialnetworks.com
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Different Affiliate marketers are actually not successful to safe Googles leading search positions, and also the reason why? Lets say you will find $ 10, 000 on the web companies trying to sell equivalent cost-effective style sneakers, and perhaps simply Ten ones will be noticed by possible buyers if their particular web sites are generally rated among the top ten about Googles or perhaps Yahoos initial result webpages.
Different Internet businesses shell out separately pertaining to weblogs, articles and also press releases to obtain one way links linked to their internet site or perhaps weblogs because they think their particular web sites will be marketed to leading search positions with one of these personal linking tactics. Even so, they could end up with paying out countless dollar along with their web sites are not around generally there but.
To get leading search positions about search engines is dependent upon a great deal of factors. One of many SEO?s substantial capabilities is the keywords and phrases you?ll want to decide on quite sensibly before you start starting other tactics. If your chosen keywords and phrases are generally highly competitive, as well as your internet site can be mental faculties brand new, it can be nearly impossible in promoting your website to the top level five in an proper period.
On-page Search engine optimisation happens involving Affiliate marketing. Is the written content distinctive and effectively published linked to your own market place location? The amount of keywords and phrases are actually found in that written content? bersetzungsservice It could be seen as a unsolicited mail by Search engines or another search engines for those who have too many keywords and phrases shown onto it. This is a beautiful idea to match your own keyword occurrence together with that regarding your competition when doing On-site Search engine optimisation.
Off-site Search engine optimisation or perhaps back link complexes are not as fundamental as most people think. They call for throughout employing various methods and strategies, and also they may be carried out these days, there is no ensure that your particular internet site will be rated highly online within the next day. The reason being search engines like Search engines retains altering its look for algorithm that it is challenging pertaining to website owners to anticipate a result. By way of example, at the start of this particular Net globe, the majority of search engines including Search engines highly evaluated back-links through the web directories. At present, it seems becoming a total waste by submitting your website to lots or perhaps a huge number of web directories since your internet site will certainly achieve little or no page ranking juice from them. By comparison, submitting your website to websites and also Blogging platforms.Zero weblogs appears to be one of the better ways to increase fast loans no credit check your website to higher rankings.
One of many least expensive methods for getting your website to the top level search positions can be method an expert webmaster or perhaps professional web marketer whom provides a full package which include all the previously mentioned netzwerkschrank talked about tactics. You?ll find so many low-cost Search engine optimisation packages available on the net given by knowledgeable Search engine optimisation pros who perform all the handiwork in your case. All you have to perform can be execute a number of lookups on the Internet and compare their particular provided Search engine optimisation packages. And you may in addition uncover that a number of consultant Search engine optimisation firms ensure your website will be on the top five inside a particular period; or perhaps they will go back a complete reimbursement to you personally. Purchasing back-links from personal linking tactics provided that you?ve got a few abilities throughout Search engine optimisation and also Affiliate marketing; or else, it might cost you a fortune.
Authored by Itwebxpert.
Itwebxpert was started throughout 04 to deal with the short growth of web site design and also increase in the world. Subsequently, it have given low cost web design, internet site maintenance providers and also low cost Off-page optimization in the the UK and also overseas.
[unable to retrieve full-text content]Registry is the database where data of programs and windows is stored. Registry cleaner is software, used to run your computer faster and smoother. Registry. ... After identifying the problems, the software with the use of its advanced technology can easily clean your registry. After this your computer will start functioning, like a new PC. After installing the software you can customize its different options according to the requirements of your computer. Many online sites ...
The business and affairs of appurtenances and casework application internet as a average for sales and administration is alleged Internet marketing. Internet has adapted the apple into a baby apple and bodies from any allotment of the apple can buy or advertise articles or services.
Internet business allows bodies aloft assertive age absolute who accept internet affiliation to a computer can alpha a business with negligible or no antecedent costs. This business is done two altered ways. One involves affairs your articles and casework as a merchant or assignment as average men accepted as affiliates. These affiliates acquire agency by accouterment a articulation of the merchants in their website and acquire money as and back a chump clicks those links and goes to the website of the merchant. It is important for this website to accompany prospects. This is done in three ways:
* Advertising: This is done on third affair websites. * Word of aperture referrals: This is done if addition anon tells you about a website or if addition writes about a website in their own website. * Passing Traffic: This is annihilation but look agent marketing.
Internet business has become so accepted and the affidavit for that are abbreviated below:
- Internet business involves actual beneath accident as you can try and again buy and best of the internet marketers started during their additional time and if acknowledged took it as the capital stream. - It takes lots of advance to alpha a accustomed business adventure but in the case of Internet business the advance is actual low or nil. All you charge is a well-designed website. - In accustomed business you are bedfast to your breadth but it is not the case with internet marketing. Anyone from any allotment of the apple can be your customer. - You can clue any announcement efforts fabricated through internet business and can abandon if it doesn?t work. - This business runs annular the alarm after any captivation of humans. You can use this chargeless time for developing yet addition website which can accomplish acceptable income.
Affiliate Marketing
This is not absolute business of a artefact but accepting agency by announcement addition business. You charge to accommodate a articulation of addition business in your website for which you will be paid and for every bang of the chump who goes into that business armpit you will be paid.
Benefits of Associate marketing:
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Some types of associate business are:
* Pay per Bang which involves acquittal back the articulation of the merchant is clicked. * Pay per Performance which involves acquittal for a defined result. * Amount per Action is the best called archetypal by abounding affiliates and is actual abutting to Pay per Bang model.
Highlights from the American Association for the Advancement of Science annual meeting in Vancouver, February 16-20
Web edition : 3:07 pm
Video games improve vision
Violent video games get a bad rap, but the gory games may have a benefit for people with vision problems, psychologist Daphne Maurer of McMaster University in Canada reported February 17. Playing the game Medal of Honor, in which the user sees scenes from the perspective of a soldier, for 40 hours over a month improved a host of visual abilities in adults who were born with cataracts.? Even though the participants had their cataracts removed when they were young, vision deficits persisted. But 40 hours of gaming that requires users to survey a wide field and react quickly to threats improved multiple visual abilities. ?It?s like reading one to two lines farther on the eye chart,? Maurer said. She and her colleagues are developing a less gory version of a video game that can do the same job without all the bloodshed. ?Laura Sanders
Bird flu studies should be published in full, WHO says
A study describing deadly lab-engineered mutations to H5N1, the virus that causes bird flu, will be published in full in the journal Science.?Bruce Alberts, editor in chief of the journal, announced the decision February 17 after the World Health Organization recommended the complete, uncensored publication of the study and another submitted to appear in Nature. The studies describe the creation of strains of the virus that can spread among mammals as normal flu does, presenting the potential for a worldwide pandemic. Though the naturally occurring form of the virus rarely infects humans, it kills about half of the people who get infected with it. The decision to publish the full results, announced at the meeting, runs contrary to that of recommendation of the U.S. National Science Advisory Board for Biosecurity, which in December called for redacted publication of the studies. The advisory board cited such concerns as the possible use of the studies? methods to make a bioweapon. Alberts said that he will follow the WHO recommendations instead of proceeding with an initial plan to publish a redacted version in mid-March. ?The aim is to publish a full version of the paper without redaction,? Alberts said. At this point, though, it?s unclear how the recommendation will affect the timing of publication. ?Nadia Drake
Fracking isn?t tainting groundwater, study finds
Several communities have reported groundwater contamination associated with natural gas produced from deep shale deposits by hydraulic fracturing, sometimes called fracking. A new study by researchers at the University of Texas at Austin concludes that such pollution results not from liquids pumped down to the shale deposits to fracture the deep rock ? as often claimed ? but instead from poor management of wastes or bore wells thousands of feet above the shale. Funded by the university with no industry contributions, the study doesn?t downplay drinking-water pollution associated with shale-gas production. But those risks ?are very similar, if not exactly the same, as the impacts that we see from conventional gas development,? said Charles ?Chip? Groat, who led the study. Groat reported his team?s findings February 16. ?Janet Raloff
Sheep producers in all locations of the United States are faced with single type of predator or an additional, whether it?s the wolf and coyote in Montana or a dog in Massachusetts. The mainly harmful of predators to a sheep farming business is the one causing the largely difficulty at that specific period and in that place.
Predation of sheep and lambs is a more serious drawback than many realize. According to facts released by the National Agricultural Statistics Service (NASS), consider the following:
- In 2004, American sheep producers lost an estimated 224,200 sheep and lambs to predators. That is more than 614 animals for every day of the week.
- Predators accounted in support of almost 37.3 percent of entire sheep and lamb losses in 2004, estimate the sheep industry more than $38 million in likely returns.
- Depredation constitute around 15 percent of the whole cost of sheep production, following single to feed and meadow expenditure.
The management of predation by wildlife is a essential factor of livestock production. Due to the changing community morals over the current past, at hand has been more of an importance on non-lethal methods in support of managing predators. The thought behind this method is to keep hold of the predators in their natural home, while defending livestock at the same instance. According to NASS, ?U.S. Farmers and ranchers spent $9.8 million in 2004 on non-lethal methods to care for their flocks.? The generally usual nonlethal methods include: Fencing, night penning, guard dogs and lamb sheds.
These non-lethal methods are aided in their duties by electric fence, electric guards and noise-making devices. However, these techniques are not a cure-all in place of depredation as a number of predators quickly adjust to sounds emitted from noise-making equipment. In reality, sheep?s major predator ? the coyote ? has been recognized to make use of group strategies to lure guard animals away from sheep.
Raising sheep for profit is not as hard as it seems. Given tried and tested techniques, even someone new to the entire thing can do it right. The trick is to divide the most basic and most important aspects of rearing sheep for profit, such as housing, fencing, feeding, and handling. They strive in an environment that follows a routine and is peaceful. Keep your sheep together to foster a sense of home. Sheep are very tame creatures. The more comfortable they are, the healthier they will be ? and this translates to profits.
Looking for more tips on sheep predators, raising sheep and how to protect your sheep? Visit the how to raise sheep site today to discover everything you need to be aware and how easy it is to raise and protect your own sheep. Just go to: www.howtoraisesheep.com
That?s a strong claim to make ? that if you do have an?email marketing list it can make your Internet business succeed, and if you don?t, it can break your business.
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Public release date: 22-Feb-2012
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